Katie and John Kelly (Eliza Coupe and Steve Howey) are ready to settle down and have kids but five years later, all they have to show for their efforts is a mountain of negative pregnancy tests and an increasingly elaborate home micro-brewing rig, which John hopes will launch his company. As they run out of traditional options and their window closing, the couple explores the daunting world of medical, spiritual, and homeopathic methods to conceive a child. With an ensemble cast that also includes Bob Stephenson, Elizabeth Rodriguez, Ed Begley Jr., Jon Daly, and the late Glenne Headly, MAKING BABIES puts a couple through the ringer of modern infertility treatments and questions whether their marriage will withstand the ultimate test.